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The toothbrush is an oral hygiene instrument used to clean the teeth and gums that consists of a head of tightly clustered bristles mounted on a handle, which facilitates the cleansing of hard-to-reach areas of the mouth.

Toothpaste, which often contains fluoride, is commonly used in conjunction with a toothbrush to increase the effectiveness of tooth brushing. Toothbrushes are available with different bristle textures, sizes and forms. Most dentists recommend using a toothbrush labelled "soft", since hard bristled toothbrushes can damage tooth enamel and irritate the gums.

The predecessor of the toothbrush is the chew stick. Chew sticks were twigs with a frayed end used to brush against the teeth, while the other end was used as a toothpick. The earliest chew sticks were discovered in Babylonia in 3500 BC, an Egyptian tomb dating from 3000 BC, and mentioned in Chinese records dating from 1600 BC.
The Greeks and Romans used toothpicks to clean their teeth and toothpick-like twigs have been excavated in Qin Dynasty tombs. Chew sticks remain common in Africa the rural Southern United States - and in the Islamic world the use of chewing stick Miswak is considered a pious action, and has been prescribed to be used before every prayer five times a day. Miswak has been used by Muslims since 7th Century AD.

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